CD28 plays a critical role in the segregation of PKCθ within the immunologic synapse

By Jianyong Huang, Pei-Fen Lo, T. Zal, N. Gascoigne, Brian A. Smith, S. Levin, H. Grey. Proceedings of the National Academy of Sciences of the United States of America, 2002

153 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/2ba821aee653fe3eb5939cc58348b6508ceede87

How researchers see this paper

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In Immunology

1. Oreste Acuto
2. F. Michel
3. J. Bluestone

In Oncology

1. J. Bluestone

Citations in the corpus

• CD28 costimulation: from mechanism to therapy (2016, background): “PDK1 in turn phosphorylates and activates PKCq, a critical downstream effector of CD28, which mediates signaling events leading to the activation of the NF-kB, AP-1, and NF-AT transcription factors (Coudronniere et al., 2000; Dodson et al., 2009; Lin et al., 2000).”
• CD28-mediated co-stimulation: a quantitative support for TCR signalling (2003, background): “, as well as TCR- and intracellular-protein-clustering event”