Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice

By J. M. Welch, Jing-Ying Lu, R. Rodriguiz, N. Trotta, J. Peça, Jin-Dong Ding, C. Feliciano, Meng Chen, J. Adams, Jianhong Luo and 5 more. Nature, 2007

814 citations recorded by the source corpus.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Clinical Psychology

View Paper: https://www.semanticscholar.org/paper/2b7816796d424bcf1fe999c9fee987ea638d3cc7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. R. Malenka

In Cellular and Molecular Neuroscience

1. R. Malenka
2. A. Kreitzer
3. Wolfram Schultz
4. Gina G. Turrigiano
5. S. Hyman
6. A. Citri
7. C. Lüscher
8. E. Nestler

In Clinical Psychology

1. Catherine Lord

Citations in the corpus

• Analysis of Grooming Behavior and Its Utility in Studying Animal Stress, Anxiety, and Depression (2009, background): “Furthermore, understanding ethological patterning of grooming also has implications for developing better mouse models of human behavioral disorders (such as obsessive-compulsive disorder, Rett or Tourette’s syndrome), and for decoding normal human nervous behaviors elicited by everyday stress (7, 8”
• Behavioural phenotyping assays for mouse models of autism (2010, background): “Mice exhibit spontaneous motor stereotypies, including circling, jumping, backflips and self-groomin”
• Striatal plasticity and basal ganglia circuit function (2008, background): “More recently, a postsynaptic scaffolding protein expressed in the striatum, Sapap3, has been implicated in OCD behaviors including pathological overgrooming and anxiety (Welch et al., 2007).”