Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism

By M. Steinhoff, N. Vergnolle, S. H. Young, M. Tognetto, S. Amadesi, H. Ennes, M. Trevisani, M. Hollenberg, J. Wallace, G. Caughey and 5 more. Nature Medicine, 2000

965 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Genetics, Immunology

View Paper: https://www.semanticscholar.org/paper/2b734f8fd31484fec238037273399da5d4233e2c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. C. Nathan
2. N. Bunnett

In Genetics

1. V. Ossovskaya
2. N. Bunnett

In Immunology

1. C. Nathan
2. R. Medzhitov
3. C. Serhan
4. Nikolaos G. Frangogiannis
5. Kevin J. Tracey
6. J. Savill

Citations in the corpus

• Inflammatory and immune pathways in the pathogenesis of periodontal disease (2014, background): “Protease-activated receptor 2 is co-expressed with substance P and calcitonin gene-related peptide on sensory nerves, where it is believed to mediate inflammation (53, 222) (Fig.”
• Points of control in inflammation (2002, background): “First, in response to pain, neurons release bioactive peptide”
• The neurobiology of itch (2006, background): “PAR 1 and PAR 2 are functional in primary afferent neurons and modulate nociceptio”
• Protease-activated receptors: contribution to physiology and disease. (2004, background): “Proteases that activate PAR1 and PAR2 can signal to these neurons in peripheral and perhaps central tissues to control inflammation and pain (11, 87, 270, 296) (Fig.”