CD4+CD25high Regulatory Cells in Human Peripheral Blood1

By C. Baecher-Allan, Julia A. Brown, G. Freeman, David A. Hafler. Journal of Immunology, 2001

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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells (2006, methodology): “Although many studies indicate that CD25 is a crucial cell surface marker for the regulatory subset (16, 17), unlike the mouse, several studies have suggested that only the CD4+ T cell subset expressing the highest levels of CD25 (termed CD25hi) have in vitro suppressive activity (16).”
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. (2009, background): “Human natural Treg cells were initially defined according to their high expression of CD25 (Baecher-Allan et al., 2001; Dieckmann et al., 2001; Jonuleit et al., 2001; Levings et al., 2001; Ng et al., 2001; Taams et al., 2001), based on the finding that murine CD25+CD4+ T cells are highly…”
Molecular Mechanisms of Treg-Mediated T Cell Suppression (2012, background): “In the following, we will focus on suppression of CD4 + CD25 − conventional T cells (Tcons).”