ADAMTS-2 functions as anti-angiogenic and anti-tumoral molecule independently of its catalytic activity

By Johanne Dubail, Frédéric Kesteloot, C. Deroanne, P. Motte, Vincent Lambert, J. Rakic, C. Lapière, B. Nusgens, A. Colige. 2010

77 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology and Allergy, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. R. Khalil
2. S. Zhong
3. A. Colige
4. M. Bekhouche
5. Hideaki Nagase
6. D. Edwards
7. Gillian Murphy

In Immunology and Allergy

1. S. Zhong
2. R. Khalil
3. M. Bekhouche
4. A. Colige

In Molecular Biology

1. R. Khalil
2. Hideaki Nagase
3. D. Edwards
4. S. Zhong

Citations in the corpus

• A Disintegrin and Metalloproteinase (ADAM) and ADAM with Thrombospondin Motifs (ADAMTS) Family in Vascular Biology and Disease (2019, background): “On the other hand, recombinant ADAMTS-2 reduces proliferation of endothelial cells, decreases branching of capillary-like structures formed by endothelial cells, and inhibits vessels formation in embryoid bodies [131].”
• The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology. (2015, background): “Beside its role during procollagen processing, the best characterized property of ADAMTS2 is its potent anti-angiogenic activity [24].”
• ADAMTS3 activity is mandatory for embryonic lymphangiogenesis and regulates placental angiogenesis (2015, unknown): “Other significant findings relating to potential functions are the relative resistance of Adamts2 mice to liver fibrosis [9], the infertility of Adamts2males [10], the expression of ADAMTS2 by activated macrophages [11], its anti-angiogenic properties [12] and its potential role in pediatric stroke ”
• The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family (2015, background): “Once again, versican heterozygosity exacerbated the phenotype seen with mice deficient in ADAMTS20 Table 1 ADAMTS genes: their chromosomal positions, major tissue expression locations, expression-inducing factors bstrates, and associations with pathologies Gene Location Expression Factors inducing o”
• Metalloproteinase‐dependent and ‐independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs‐15 (2015, background): “Conversely, the antiangiogenic actions of ADAMTS-2 do not require its metalloproteinase function.(15) One of the likely contributions to the pro-tumorigenic effects of ADAMTS-1 is its ability to cleave the ectodomain of syndecan-4.”