Oxidase Activity of Polymer-Coated Cerium Oxide Nanoparticles

By Atul Asati, S. Santra, C. Kaittanis, S. Nath, J. Perez. Angewandte Chemie, 2009

801 citations recorded by the source corpus.

Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase-like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB).

Subfields: Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2af94f614d01c3020e18c102af131a319561ecdf

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Citations in the corpus

• Surface-Charge-Dependent Cell Localization and Cytotoxicity of Cerium Oxide Nanoparticles (2010, positive): “Previously, we have reported that polymer-coated nanoceria displays unique oxidase-like behavior at slightly acidic pH.(22) Therefore, in view of this oxidase-like property at acidic pH, intracellular distribution of the polymer-coated nanoceria into the lung carcinoma’s lysosomes may be the reason ”
• Surface modification of nanozymes (2017, background): “Third, dopamine can be used as chromogenic substrate to study the peroxidase/oxidase activity of enzymes, and the oxidation product has an absorbance peak at 480 nm [26, 105, 106].”