Accelerated wound healing by injectable microporous gel scaffolds assembled from annealed building blocks

By D. Griffin, W. Weaver, P. Scumpia, D. Di Carlo, T. Segura. Nature Materials, 2015

840 citations recorded by the source corpus.

Summary Injectable hydrogels can provide a scaffold for in situ tissue regrowth and regeneration, however these injected materials require gel degradation prior to tissue reformation limiting their ability to provide physical support. We have created a new class of injectable biomaterial that circumvents this challenge by providing an interconnected microporous network for simultaneous tissue reformation and material degradation. We assemble monodisperse micro-gel building blocks into an interconnected microporous annealed particle (MAP) scaffold. Through microfluidic formation, we tailor the chemical and physical properties of the building blocks, providing downstream control of the physical and chemical properties of the assembled MAP scaffold. In vitro, cells incorporated during MAP scaffold formation proliferated and formed extensive 3D networks within 48 hours. In vivo, the injectable MAP scaffold facilitated cell migration resulting in rapid cutaneous tissue regeneration and tissue structure formation within 5 days. The combination of microporosity and injectability achieved with MAP scaffolds will enable novel routes to tissue regeneration in vivo and tissue creation de novo.

Subfields: Biomaterials, Biomedical Engineering

View Paper: https://www.semanticscholar.org/paper/2ae9cada26a15d50c5d1d841a60953151eeb083f

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In Biomaterials

1. K. Yue
2. Ali Tamayol
3. Ali Khademhosseini

In Biomedical Engineering

1. Ali Tamayol
2. K. Yue
3. Ali Khademhosseini

Citations in the corpus

• In situ Forming Injectable Hydrogels for Drug Delivery and Wound Repair (2018, neutral): “182 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 182 ews theme issue on "Skin-Associated Drug Delivery".”
• Drug Delivery Systems and Materials for Wound Healing Applications (2018, positive): “To avoid these steps, the development of injectable scaffolds that can encapsulate cells, form tissue constructs in situ, and promote cell migration and organization has been recently demonstrated [87].”
• Modeling Physiological Events in 2D vs. 3D Cell Culture. (2017, methodology): “Both ribbon-shaped and micro-bead-like building blocks were used to create 3D scaffolds that support nutrient diffusion, cell proliferation, ECM production, and wound healing (44).”