Neutrophil recruitment and function in health and inflammation

By E. Kolaczkowska, P. Kubes. Nature reviews. Immunology, 2013

5,106 citations recorded by the source corpus.

Neutrophils have traditionally been thought of as simple foot soldiers of the innate immune system with a restricted set of pro-inflammatory functions. More recently, it has become apparent that neutrophils are, in fact, complex cells capable of a vast array of specialized functions. Although neutrophils are undoubtedly major effectors of acute inflammation, several lines of evidence indicate that they also contribute to chronic inflammatory conditions and adaptive immune responses. Here, we discuss the key features of the life of a neutrophil, from its release from bone marrow to its death. We discuss the possible existence of different neutrophil subsets and their putative anti-inflammatory roles. We focus on how neutrophils are recruited to infected or injured tissues and describe differences in neutrophil recruitment between different tissues. Finally, we explain the mechanisms that are used by neutrophils to promote protective or pathological immune responses at different sites.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/2aa0ba14f2544cdb5ba83a924a51128740d10d6e

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Citations in the corpus

Diverse stimuli engage different neutrophil extracellular trap pathways (2017, background): “They are terminally differentiated, short lived cells that emerge from the bone marrow ready to react to the presence of pathogens (Amulic et al., 2012; Kolaczkowska and Kubes, 2013).”
Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance (2017, background): “These receptors are important for the binding of PMNs to the extracellular matrix in order to facilitate adhesion and transmigration from the blood into infected tissues (Kolaczkowska and Kubes, 2013; Winograd-Katz et al., 2014).”
Roles of the immune system in cancer: from tumor initiation to metastatic progression (2018, background): “They are among the first immune cells to be recruited to damaged tissue, where they can eliminate pathogens and modulate inflammation by mechanisms such as phagocytosis, secretion of antibacterial proteins, deposit of neutrophil extracellular traps (NETs), and exocytosis of protease-containing granu”
Skin Acute Wound Healing: A Comprehensive Review (2019, background): “In the final stages of their lifespan, they are cleared from the circulation in the liver, spleen, and bone marrow [45].”
Mesenchymal stromal cells: sensors and switchers of inflammation. (2013, neutral): “During the acute phase of inflammation, neutrophils migrate toward the site of inflammation where they accumulate within minutes and act mainly through phagocytosis (Kolaczkowska and Kubes, 2013).”
The Multifaceted Functions of Neutrophils (2013, background): “In thermal injury, released mitochondrial formyl peptides serve as DAMPs that contribute to inflammation-induced tissue damage (11).”
Neutrophil: A Cell with Many Roles in Inflammation or Several Cell Types? (2018, background): “…immunogenic cell death, after some types of anticancer therapy (Galluzzi et al., 2012; Bezu et al., 2015; Garg et al., 2017a), a damaged cancer cell produces specific inflammatory chemokines to recruit neutrophils as first innate immune cells (Kolaczkowska and Kubes, 2013; Garg et al., 2017b).”
Reactive Oxygen Species and Neutrophil Function. (2016, background): “However, NETs are implicated in an ever-increasing range of inflammatory conditions in which they are postulated to have deleterious effects (2, 97).”
Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “The concept of sentinel neutrophils being recruited into peripheral tissue in homeostasis is intriguing, and in homeostasis neutrophils may be actively crawling along and patrolling the lung vasculature, but not the spleen or liver (29).”