Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex

By L. Zeng, Lin Xu, D. Gutmann, M. Wong. Annals of Neurology, 2008

620 citations recorded by the source corpus.

Subfields: Molecular Biology, Pathology and Forensic Medicine, Physiology

View Paper: https://www.semanticscholar.org/paper/2a70485299e3ac83838d456121849188ba1ce579

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. R. A. Saxton
2. Rajiv K. Tonk
3. Vivek Panwar
4. Manini Bhatt
5. Shinjinee Sengupta
6. Manoj Garg
7. Aishwarya Singh
8. A. Raza

In Pathology and Forensic Medicine

1. David M. Sabatini

In Physiology

1. David M. Sabatini
2. R. A. Saxton

Citations in the corpus

• mTOR Signaling in Growth, Metabolism, and Disease. (2017, background): “Indeed, mTORC1 hyperactivation in mice through neural loss of Tsc1 or Tsc2 leads to severe epileptic seizures that are prevented by rapamycin treatment (Zeng et al., 2008), and mutations in components of the GATOR1 and KICSTOR complexes have been linked to epilepsy in humans (Basel-Vanagaite et al.”
• Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease (2023, background): “190 The mutations in components of the KICSTOR and GATOR1 complexes were associated with Fig.”
• mTOR Signaling in Growth, Metabolism, and Disease (2017, background): “Indeed, mTORC1 hyperactivation in mice through neural loss of Tsc1 or Tsc2 leads to severe epileptic seizures that are prevented by rapamycin treatment (Zeng et al., 2008), and mutations in components of the GATOR1 and KICSTOR complexes have been linked to epilepsy in humans (Basel-Vanagaite et al.”