Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock

By Manuel, Ivers, Ryant, Guyen, Uzanne, Avstad, Ulie, Essler, Lexandria, Uzzin and 6 more. 2001

8,856 citations recorded by the source corpus.

Subfields: Critical Care and Intensive Care Medicine, Epidemiology, Surgery

View Paper: https://www.semanticscholar.org/paper/293aa63e1ce0b0f8bc7cd3ab25209c1847a46131

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In Critical Care and Intensive Care Medicine

In Epidemiology

In Surgery

Citations in the corpus

Impact of delayed transfer of critically ill patients from the emergency department to the intensive care unit* (2007, background): “(1) of early goal-directed therapy in severe sepsis, for example, the key factor under investigation was the rapid institution of the goaldirected therapy by qualified clinical personnel regardless of patient location as opposed to the transfer to a specific location like the ICU to institute the th”
From vital signs to clinical outcomes for patients with sepsis: a machine learning basis for a clinical decision support system (2014, methodology): “6 22 For this reason, updated consensus international guidelines for the treatment of severe sepsis include new recommendations for early lactate measurement among all adults with sepsis.”
Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock (2004, background): “This protocol was associated with an improvement in survival (5).”
Fluid resuscitation in septic shock: A positive fluid balance and elevated central venous pressure are associated with increased mortality* (2011, methodology): “Was the 16% absolute reduction in mortality with EGDT a result of achieving a central venous pressure of 13.8 rather than 11.8 mm Hg or might it be that other factors, including large differences in the use of inotropes and blood transfusion, drove the treatment effect (11)?”
The Sequential Organ Failure Assessment score for predicting outcome in patients with severe sepsis and evidence of hypoperfusion at the time of emergency department presentation (2009, methodology): “It is estimated that one half of sepsis hospitalizations originate in the emergency department (ED), underscoring the importance of developing and evaluating accurate and reliable methods for assessing illness severity and prognosis to allow for proper allocation of limited hospital resources (3–5) ”
Axes of a revolution: challenges and promises of big data in healthcare (2020, background): “Another example is the prediction of sepsis, as the early administration of antibiotics and intravenous fluids is considered crucial for the management of sepsis 89 .”