miR‐15b and miR‐16 modulate multidrug resistance by targeting BCL2 in human gastric cancer cells

By L. Xia, De-xin Zhang, R. Du, Yanglin Pan, Lina Zhao, Shiren Sun, L. Hong, Jie Liu, D. Fan. International Journal of Cancer, 2008

702 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/291df68e578587ad3ee03ae6c5ca035d05316b6c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. P. Murphy
2. Leigh-Ann MacFarlane
3. Marcus E. Peter
4. Benjamin Boyerinas

In Molecular Biology

1. Quan Zou
2. P. Murphy
3. Leigh-Ann MacFarlane
4. Marcus E. Peter
5. Benjamin Boyerinas

Citations in the corpus

• MicroRNA: Biogenesis, Function and Role in Cancer (2010, background): “It is hypothesized that BCL2 repression via miR15b/miR16-2 reduces a cell’s sensitivity to drug-induced apoptosis [263, 270-272].”
• Multi-drug resistance in cancer chemotherapeutics: mechanisms and lab approaches. (2014, background): “Moreover, the over-expression of miR-15b or miR-16 could sensitize SGC7901/VCR cells to VCR-induced apoptosis by targeting BCL2 [18].”
• MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review (2012, unknown): “This first evidence was followed by many other studies (Chen et al, 2010a; Kovalchuk et al, 2008; Xia et al, 2008).”
• The role of let-7 in cell differentiation and cancer. (2010, background): “MiR-15b and miR-16 target the antiapoptotic protein Bcl2 and reduce its expression level (Xia et al. 2008), while miR-1 overexpression sensitizes A549 lung cancer cells to doxorubicininduced death by reducing levels of the anti-apoptotic protein Mcl-1 (Nasser et al.”
• Biological functions of microRNAs: a review (2011, background): “miR-15b and miR-16, which are down-regulated in human gastric cancer cells, play a role in the development of multidrug resistance (MDR) by modulation of apoptosis via targeting BCL2 [ 70 ].”
• Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAs (2010, background): “In particular, the following target proteins were downregulated: PTEN which is known to be targeted by miR-21 [28,29], cyclin D1 which is known to be targeted by miR-100, miR-99a and miR-223 [30] and Bcl-2 which is known to be targeted directly by miR-34, miR-181b and miR16 [31,32,33] or indirectly ”