Dissecting Temporal and Spatial Control of Cytokinesis with a Myosin II Inhibitor

By A. Straight, Amy Cheung, John Limouze, Irene Chen, N. Westwood, J. Sellers, T. Mitchison. Science, 2003

1,441 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/2882c925988e2110271262c1018a2844052b3a84

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

R. Fässler

In Molecular Biology

Citations in the corpus

Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes (2006, neutral): “One might fairly ask why the utilization of reactive oxidants has been so evolutionarily durable and how oxidants can manage to selectively relay a diverse array of signaling cassettes, especially because the different Noxs presumably produce the same oxidant species perceived by the cell as an…”
Chromothripsis and kataegis induced by telomere crisis (2015, neutral): “Indeed, when ingression was blocked with the actomyosin inhibitor blebbistatin (Straight et al., 2003), the dicentric chromosomes clearly remained intact (0/24 resolution events) (Figure 1F, Movie S1, panel 1).”
The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. (2009, methodology): “To analyze Numb distribution immediately after mitosis, we treated PKH cells with blebbistatin, a small molecule that arrests cytokinesis and leads to the formation of binucleated cells (Straight et al., 2003).”
Author Manuscript (2013, background): “Blebbistatin (1-phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-β]-7-methylquinolin-4-one) is a newly discovered reversible inhibitor of myosin II and other myosin isoforms [9, 23, 32, 33].”
Integrin-mediated mechanotransduction (2016, background): “FA maturation is a coordinated process requiring further integrin clustering, F-actin bundling, and the reinforcement of the linkages between integrin and actomyosin (Straight et al., 2003; Choi et al., 2008; Iskratsch et al., 2013).”
Spatiotemporal feedback between actomyosin and focal-adhesion systems optimizes rapid cell migration. (2006, neutral): “To decrease myosin II activity, cells were treated with low levels of the myosin II ATPase inhibitor blebbistatin (1 or 5 mM) (Straight et al., 2003).”