The genetics of inbreeding depression

By D. Charlesworth, John H. Willis. Nature reviews genetics, 2009

1,962 citations recorded by the source corpus.

Subfields: Genetics, Plant Science

View Paper: https://www.semanticscholar.org/paper/28721e951eb41a3a5cbf03ed2a8a4ecfa2e57928

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. J. L. Bouzat
2. P. Hedrick
3. S. Aitken
4. Jiayang Li
5. M. Whitlock
6. Shawn M. Kaeppler
7. R. Fredrickson
8. L. Möller

In Plant Science

1. Jiayang Li
2. M. Whitlock
3. Shawn M. Kaeppler
4. J. L. Bouzat
5. Jue Ruan
6. P. Hedrick
7. B. Kempenaers
8. S. Aitken

Citations in the corpus

• Inbreeding depression of sexually selected traits and attractiveness in the zebra finch (2010, background): “The former has received most support (Charlesworth & Willis 2009).”
• Inbreeding and runs of homozygosity: A possible solution to an old problem (2014, background): “, 1995), reduction in the population mean for traits closely related to fitness (Charlesworth and Willis, 2009), higher incidence of homozygous recessive defects (Alvarez et al.”
• Associations of autozygosity with a broad range of human phenotypes (2019, neutral): “Nature Communications, 10(1), [4957 (2019)].”
• Genome analysis of Taraxacum kok-saghyz Rodin provides new insights into rubber biosynthesis (2018, background): “These observations indicate that these heterozygous regions or genes are possibly related to inbreeding depression caused by homozygous recessive deleterious effects [18].”
• Assisted Gene Flow to Facilitate Local Adaptation to Climate Change (2013, background): “…with small effective population sizes are expected to be less able to adapt quickly to environmental changes than large populations because of inbreeding depression (Charlesworth & Willis 2009) and a lack of standing genetic variation (Weber & Diggins 1990, Frankham 2005, Willi et al. 2006).”
• Remarkably low genetic diversity and strong population structure in common bottlenose dolphins (Tursiops truncatus) from coastal waters of the Southwestern Atlantic Ocean (2014, background): “The importance of genetic variation relates to multiple aspects of population resilience and persistence, and is usually assumed to be critical for long-term fitness and adaptation (Franklin 1980; Charlesworth and Willis 2009), although some studies have shown that minimal genetic variation is not a”
• Genetic rescue guidelines with examples from Mexican wolves and Florida panthers (2009, background): “With advances in identifying genes negatively influencing fitness and measuring their effect in other organisms, the genetic architecture of detrimental variation in endangered species should become known in the future (Charlesworth and Willis 2009).”
• The Contemporary Evolution of Fitness (2018, background): “Another effect of small population size can be an increase in inbreeding, which can have negative effects on fitness through the increased expression of recessive deleterious mutations and the decreased expression of overdominance (Reed & Frankham 2003, Charlesworth & Willis 2009).”
• Conservation genetics of population bottlenecks: the role of chance, selection, and history (2010, background): “This can occur through inbreeding depression or increases in the genetic load of populations (Ralls et al. 1979; Kirkpatrick and Jarne 2000; Fox et al. 2008; Charlesworth and Willis 2009; Hedrick and Fredrickson 2010).”
• Heterosis: Many Genes, Many Mechanisms—End the Search for an Undiscovered Unifying Theory (2012, background): “The conceptual opposite of heterosis is inbreeding depression [31].”