Alternative splicing: increasing diversity in the proteomic world.

By Brenton R. Graveley. Trends in Genetics, 2001

1,228 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/28673ee289bb8573f2b9814a447e0c6ebca909cf

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Citations in the corpus

Trinity: reconstructing a full-length transcriptome without a genome from RNA-Seq data (2011, neutral): “In addition, insect transcriptomes exhibit complex alternative splicing patterns 28 .”
Comparative analysis identifies exonic splicing regulatory sequences--The complex definition of enhancers and silencers. (2006, background): “Alternative splicing increases the diversity of the transcriptome within and between cells and adds an additional regulatory dimension to the expression pattern of an organism (Ast, 2004; Graveley, 2001).”
Proteomic analysis of the mammalian nuclear pore complex (2002, background): “Alternative splicing, an event very rare in yeast genes (Graveley, 2001) but seen in some mammalian nucleoporins (Hu and Gerace, 1998; Fontoura et al., 1999) may further increase vertebrate nucleoporin diversity in a manner analogous to the gene duplications seen in yeast.”
Promoter Choice Determines Splice Site Selection in Protocadherin α and γ Pre-mRNA Splicing (2002, background): “Protein diversity is Department of Molecular and Cellular Biology generated by a variety of mechanisms, such as alternaHarvard University tive promoter activation and alternative pre-mRNA splicCambridge, Massachusetts 02138 ing (Graveley, 2001).”
Function of alternative splicing. (2005, neutral): “In Drosophila, the Down syndrome cell adhesion molecule (DSCAM) can potentially generate 38016 isoforms due to alternative splicing (Celotto and Graveley, 2001).”
Non‐coding RNAs: the architects of eukaryotic complexity (2001, background): “While the repertoire of protein isoforms expressed in the higher organisms is greatly increased by alternative splicing (Graveley, 2001), the other striking feature of the evolution of the higher organisms, which has been largely overlooked to date, is the huge increase in the amount of non-protein-”
A genomic view of alternative splicing (2002, background): “Notable examples of combinatorial alternative splicing of multiple cassettes of exons, generating up to 40,000 isoforms of a single gene, have recently been discovered in the nervous system, including Dscam (axonal guidance receptor in Drosophila ) and neurexin (neuropeptide receptor”
Intrinsically disordered proteins in human diseases: introducing the D2 concept. (2008, background): “NMR characterization of the full-length recombinant murine prion protein, mPrP(23-231).”