Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase.

By D. Salonga, K. Danenberg, Martin J Johnson, R. Metzger, S. Groshen, D. Tsao-Wei, H. Lenz, G. Leichman, L. Leichman, R. Diasio and 3 more. Clinical Cancer Research, 2000

880 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/2856f570daa78bd0bd358cd2cd1db8b4dd46201f

Citations in the corpus

• 5-Fluorouracil: mechanisms of action and clinical strategies (2003, unknown): “Importantly, the study by Salonga et al.80 also indicated that DPD, TS and TP are each independent predictive markers of 5-FU response and that measurement of all three markers markedly enhanced the ability to predict tumour response to 5-FU-based chemotherapy. p53.”