Diffuse Optics for Tissue Monitoring and Tomography

By Turgut Durduran, R. Choe, W. Baker, A. G. Yodh. Reports on progress in physics. Physical Society, 2010

1,159 citations recorded by the source corpus.

This review describes the diffusion model for light transport in tissues and the medical applications of diffuse light. Diffuse optics is particularly useful for measurement of tissue hemodynamics, wherein quantitative assessment of oxy- and deoxy-hemoglobin concentrations and blood flow are desired. The theoretical basis for near-infrared or diffuse optical spectroscopy is developed, and the basic elements of diffuse optical tomography are outlined. We also discuss diffuse correlation spectroscopy, a technique whereby temporal correlation functions of diffusing light are transported through tissue and are used to measure blood flow. Essential instrumentation is described, and representative brain and breast functional imaging and monitoring results illustrate the workings of these new tissue diagnostics.

Subfields: Biomedical Engineering, Physiology, Radiology, Nuclear Medicine and Imaging

View Paper: https://www.semanticscholar.org/paper/2841f753d7fc72c5a4edab2d79d4e4a2842b2416

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In Biomedical Engineering

In Physiology

In Radiology, Nuclear Medicine and Imaging

Citations in the corpus

A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology (2014, background): “Durduran et al. (2010) demonstrated that PaCO2 changes affect the cerebral and extracerebral compartment differently, i.e. an increase in PaCO2 (hypercapnia) led to a significant increase in CBF, but only to a negligible increase in scalp blood flow (SBF).”
Time domain functional NIRS imaging for human brain mapping (2014, positive): “diffusion, random walk, Monte Carlo) should be used to correctly interpret NIRS signals unraveling the absorption from the diffusive contribution (Durduran et al., 2010; Martelli et al., 2009).”
A brief review on the history of human functional near-infrared spectroscopy (fNIRS) development and fields of application (2012, neutral): “The literature on the diffusion model of light transport in tissues has been recently reviewed (Durduran et al., 2010).”
Diffuse correlation spectroscopy for non-invasive, micro-vascular cerebral blood flow measurement (2013, positive): “In brain studies, the combination of NIRS/DOS and DCS permits estimation of cerebral blood flow (CBF = BFI), oxygen extraction fraction (OEF), and the cerebral metabolic rate of oxygen extraction (CMRO2) based on combined data from NIRS/DOS and DCS (Durduran et al., 2010a).”
Vibrational spectroscopic imaging of living systems: An emerging platform for biology and medicine (2015, background): “By modeling photon diffusion in turbid tissue, molecule-specific information can be obtained through approximately extracting absorption from the elastic scattering of photons (83).”