H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase

By Guangdong Yang, Lingyun Wu, B. Jiang, Wei Yang, J. Qi, Kun Cao, Q. Meng, A. Mustafa, W. Mu, Shengming Zhang and 2 more. Science, 2008

2,147 citations recorded by the source corpus.

Studies of nitric oxide over the past two decades have highlighted the fundamental importance of gaseous signaling molecules in biology and medicine. The physiological role of other gases such as carbon monoxide and hydrogen sulfide (H2S) is now receiving increasing attention. Here we show that H2S is physiologically generated by cystathionine γ-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H2S levels in the serum, heart, aorta, and other tissues. Mutant mice lacking CSE display pronounced hypertension and diminished endothelium-dependent vasorelaxation. CSE is physiologically activated by calcium-calmodulin, which is a mechanism for H2S formation in response to vascular activation. These findings provide direct evidence that H2S is a physiologic vasodilator and regulator of blood pressure.

Subfields: Biochemistry, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/28293b9914aca5510058d0d49c32719086550658

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. B. Paul
2. P. Nagy
3. P. Moore
4. Ling-Xia Li
5. S. Snyder
6. C. Winterbourn
7. P. Rose
8. Rui Wang

In Pathology and Forensic Medicine

1. B. Paul
2. P. Nagy
3. P. Moore
4. Ling-Xia Li
5. S. Snyder
6. C. Winterbourn

Citations in the corpus

• Hydrogen sulfide-linked sulfhydration of NF-κB mediates its anti-apoptotic actions (2012, background): “CSE knockout mice (CSE-/-) display hypertension and a major decrease in endothelial derived relaxed factor activity, establishing H2S as an important vasorelaxant (Szabo, 2007; Yang et al., 2008).”
• Hydrogen sulfide and cell signaling. (2011, background): “This enzyme occurs in cultured vascular smooth muscle cells (37), but the idea that this could be the source of the H2S generated naturally to control blood vessel caliber seems unlikely.”
• Redox chemistry of biological thiols (2010, background): “As with NO and CO it has vasorelaxant properties, but unlike NO or CO it acts via opening KATP channels [210,211].”
• Exogenous hydrogen sulfide alleviates salt stress in wheat seedlings by decreasing Na+ content (2015, background): “Additional information on K ? channel activities induced through H 2 S has been obtained in mammals (Yang et al. 2008).”
• Hydrogen sulfide counteracts chlorophyll loss in sweetpotato seedling leaves and alleviates oxidative damage against osmotic stress (2009, background): “For example, Yang et al. (2008) provided direct evidence that H2S is a physiologic vasodilator and regulator of blood pressure.”