Cell–cell and intracellular lactate shuttles

By G. Brooks. Journal of Physiology, 2009

757 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/28017605c41fe4c5dc2b0e01aced38f7828acb02

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Citations in the corpus

Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches (2019, background): “Hence, it requires a specific transport mechanism provided by proton-like MCTs (83, 84) It was identified that lactate shuttle is driven by a concentration and pH gradient or by the cellular redox state in rat skeletal muscle (28).”
Fiber types in mammalian skeletal muscles. (2011, background): “According to an accepted view, fast glycolytic fibers produce and extrude lactate that is taken up and oxidized by slow oxidative fibers (cell-to-cell lactate shuttle hypothesis) (106, 609).”
The SLC16 gene family - structure, role and regulation in health and disease. (2013, background): “MCTs may be involved in shuttling lactate between different cell types within a tissue There is increasing evidence that MCTs facilitate the shuttling of lactic acid between cells that produce it and those that use it within the same tissue (Bergersen, 2007; Brooks, 2009).”
Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review). (2012, background): “However, glycolysis, an ancient energy production pathway preserved in evolution, still affects energy metabolism in certain human organs and tissues, such as the brain, liver and muscle (9,10), and is also a major energy production pathway in anaerobic bacteria.”
The Science and Translation of Lactate Shuttle Theory. (2018, background): “Rather, the association between hyperlactatemia and severity of injury or illness is traceable to assumptions of O2 debt theory, now approaching 100 years of age (Hill, 1924; Meyerhof, 1920), that are contrary to new ideas involving the lactate shuttle mechanism (Brooks, 1984, 2009).”
The monocarboxylate transporter family—Role and regulation (2012, background): “The reader is referred elsewhere to a fuller account of the arguments in favor and against the intracellular lactate shuttle hypothesis (5, 16, 20, 21).”
Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. (2011, background): “…the transfer of lactate between glycolytic and oxidative muscle fibers as early as the mid-1980s—has now been extended to several other biological systems and includes intracellular lactate shuttles, cell-cell lactate shuttles, and interorgan lactate shuttles (see Brooks, 2009 for review).”
Astrocyte-neuron lactate transport is required for long-term memory formation (2011, neutral): “Thus, in agreement with Brooks (2009), we propose that glycolytic and oxidative pathways should be viewed as linked, as opposed to alternative processes also with the astrocyte-neuron network.”
Lactate metabolism in human health and disease (2022, background): “Disrupting Na(+), HCO(3)(-)-cotransporter NBCn1 (Slc4a7) delays murine breast cancer development.”