The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell Differentiation

By Pin Wang, Yiquan Xue, Yanmei Han, Li Lin, Cong Wu, Sheng Xu, Zhengping Jiang, Junfang Xu, Qiuyan Liu, Xuetao Cao. Science, 2014

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Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2 (2016, methodology): “RNA pull-down assays were performed as described (25,26).”
A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB phosphorylation and suppresses breast cancer metastasis. (2015, background): “Align with our findings, another cytoplasmic lncRNA, lnc-DC, directly blocks STAT3 phosphorylation by SHP1 and inhibits STAT3 activation (Wang et al., 2014).”
Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels (2019, background): “Knockout of lnc-DC promotes the binding of SHP1 and STAT3, thereby enhancing the dephosphorylation of STAT3, whereas overexpression of lnc-DC attenuates their binding, preventing dephosphorylation of STAT3 Tyr705, and activating downstream transcriptional activity (Figure 8C) [116].”
The multidimensional mechanisms of long noncoding RNA function (2017, background): “lnc-DC was found to regulate the expression of genes involved in dendritic cell (DC) differentiation [49].”
Mechanisms of long noncoding RNA function in development and disease (2016, background): “Lnc-DC LincRNA HEATR6 Cytoplasm Transcription factor Dendritic cell differentiation [81]”