The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway
By L. E. Nelson, T. Guo, Jun Lu, Clifford B. Saper, Nicholas P. Franks, M. Maze. Nature Neuroscience, 2002
595 citations recorded by the source corpus.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience
View Paper: https://www.semanticscholar.org/paper/27574f47c9ed2ecd21248f48fb640da59bb93c0a
How researchers see this paper
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In Cellular and Molecular Neuroscience
- Giri Panamoottil Krishnan
- Maxim Bazhenov
- Igor Timofeev
- Sylvain Chauvette
- Sydney S. Cash
- Melanie Boly
- Pierre Boveroux
- Eric Halgren
In Cognitive Neuroscience
- Maxim Bazhenov
- Giri Panamoottil Krishnan
- Eric Halgren
- Igor Timofeev
- Melanie Boly
- Audrey Vanhaudenhuyse
- Marie-Aurélie Bruno
- Sylvain Chauvette
Citations in the corpus
- Functional Neuroanatomy of the Noradrenergic Locus Coeruleus: Its Roles in the Regulation of Arousal and Autonomic Function Part I: Principles of Functional Organisation (2008, background): “1) the LC plays an important role in maintaining arousal [256, 257].”
- Breakdown of within- and between-network Resting State Functional Magnetic Resonance Imaging Connectivity during Propofol-induced Loss of Consciousness (2010, result): “Our results are also in agreement with the concept of anesthetic agents mediating hypnotic effects by activating subcortical sleep-promoting neurons.(7,66,67) However, the present study was not designed to investigate the precise mechanisms of modifications in thalamocortical interactions.”
- Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial. (2007, background): “04 RASS score within 1 point of physician goal, % (IQR)b 67 (50-85) 55 (8-67) .”
- Cellular and neurochemical basis of sleep stages in the thalamocortical network (2016, background): “Propofol inhibits the activity of the tuberomammillary nucleus (Nelson et al., 2002), although its action on ventrolateral preoptic nucleus neurons (Liu et al.”
- Histamine in the nervous system. (2008, background): “propofol) (511) is attributed to actions on GABAergic afferents to the TM nucleus, with one key to this action being the low expression of the GABAAR -subunit (667).”
- General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal (2008, unknown): “It has recently been discovered that this same pattern of firing pertains during anaesthetic-induced LO”