AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol.

By Shubha Anand, Sue Penrhyn-Lowe, A. Venkitaraman. Cancer Cell, 2003

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Aurora-kinase inhibitors as anticancer agents (2004, background): “and overexpression of the wild-type kinase can compromise spindle-checkpoint functio”
Aurora-A — A guardian of poles (2005, background): “Overexpression of Aurora-A also leads to cytokinesis failure, resulting in formation of binucleated cell”
HEF1-dependent Aurora A activation induces disassembly of the primary cilium. (2007, neutral): “AurA amplification or activation is common in many cancers characterized by centrosomal amplification and genomic instability (Anand et al., 2003; Goepfert et al., 2002; Gritsko et al., 2003).”
Roles of Aurora Kinases in Mitosis and Tumorigenesis (2007, background): “Aurora Kinases in Centrosome Amplification and Aneuploidy Overexpression of Aurora-A causes centrosome amplification both in cell cultures and in rat mammary model (89-91).”
The cellular geography of Aurora kinases (2003, background): “Two recent studies indicate that overexpression of Aurora A is unlikely to trigger centrosome amplification directly, but instead leads to mitotic abnormalities that culminate in the failure of cytokinesis and the production of tetraploid cell”