Cytokine-induced sickness behavior: where do we stand?

By Robert Dantzer. Brain, behavior, and immunity, 2001

845 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Neurology

View Paper: https://www.semanticscholar.org/paper/2734b4fcfab77a955eecf5a7ed543865a48e20de

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

In Biological Psychiatry

In Neurology

Citations in the corpus

The Darwinian concept of stress: benefits of allostasis and costs of allostatic load and the trade-offs in health and disease. (2005, background): “It has been suggested that repeated immune stimulation also makes the brain more sensitive to other classes of stimuli, a phenomenon known as cross-sensitization [216].”
Immune System to Brain Signaling: Neuropsychopharmacological Implications (2011, background): “…Behavior A rich database has been developed that substantiates the capacity of pro-inflammatory cytokines to induce, in addition to fever and activation of the hypothalamic-pituitary-adrenal (HPA) axis, a constellation of behavioral symptoms referred to as sickness behavior (Dantzer, 2001).”
Stress and health: psychological, behavioral, and biological determinants. (2005, background): “…-PA Author M anuscript N IH -PA Author M anuscript N IH -PA Author M anuscript pathogens, but more recently, it has become clear that proinflammatory cytokines are both sufficient and necessary (i.e., even absent infection or fever) to generate sickness behavior (Dantzer 2001, Larson & Dunn 2001).”
The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine (2006, background): “19 ‘Sickness behavior’ is an animal model of depression showing symptoms such as lack of drive, lack of appetite, decrease of weight, and fatigue etc”
Acute phase responses of passerine birds: characterization and seasonal variation (2007, background): “…Frafield and Kaplanski (1998), 22 Johnson et al. (1993), 23 Jones et al. (1983), 24 Leshchinksy and Klasing (2001), 25 Owen-Ashley et al. (2006), 26 Dantzer (2001), 27 Hart (1988), 28 Kent et al. (1992), 29 Benson et al. (1993), 30 Klasing et al. (1987), 31 Bertrand et al. (2006), 32 Bonneaud et…”
The behavioral immune system: Current concerns and future directions (2018, background): “…reflect a well‐orchestrated constellation of behaviors that function to conserve energy, mitigate further bodily damage from infection, and avoid injury or predation while in a weakened state (Dantzer, 2001; Dantzer & Kelley, 2007; Kluger & Rothenburg, 1979; Medzhitov, Schneider, & Soares, 2012).”
When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. (2011, background): “infection or cytokine administration in laboratory animals (103).”
Handbook of cultural developmental science (2010, background): “Reciprocally, infections themselves promote malnutrition by reducing child appetite, eroding gut integrity and nutrient absorption, and claiming energy costs for the host's response to illness (Campbell, Elia, and Lunn, 2003; Dantzer, 2001).”
Cytokine-induced sickness behavior. (2003, background): “Substantial progress has been made in defining sickness behaviors and establishing a role for proinflammatory cytokines in inducing these behaviors (reviewed in Dantzer, 2001; Dantzer, Konsman, Bluth�e e, & Kelley, 2000; Konsman, Parnet, & Dantzer, 2002; Larson & Dunn, 2001).”