Inaugural Article: Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease

By R. Thimme. 2002

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Immunobiology and pathogenesis of viral hepatitis. (2006, background): “For example, viral persistence has been associated with primary failure to efficiently mount virus-specific CD4 and CD8 T cell responses in both HCV-infected chimpanzees and in a patient who was studied prospectively following accidental needlestick exposure to HCV (8, 78, 130).”
Memory CD8+ T Cells Are Required for Protection from Persistent Hepatitis C Virus Infection (2003, background): “Virus clearance in humans and chimpanzees has been linked in most studies to the onset of sustained HCV-specific CD4 and CD8 T cell responses (2–6) and an increase in IFNmRNA levels in the liver (2).”
Interferon signaling and treatment outcome in chronic hepatitis C (2008, background): “Nevertheless, despite the activation of the endogenous IFN system, the virus is not cleared from chronically infected animals (18).”
Regulating Intracellular Antiviral Defense and Permissiveness to Hepatitis C Virus RNA Replication through a Cellular RNA Helicase, RIG-I (2005, background): “This response is an important component of the acute hepatic antiviral defenses that are triggered in vivo within days of exposure to HCV (2) and is therefore likely to contribute to the resolution of acute infection (26).”