Insights into the molecular basis of leukocyte tethering and rolling revealed by structures of P- and E-selectin bound to SLe(X) and PSGL-1.

By W. Somers, Jin Tang, G. Shaw, R. Camphausen. Cell, 2000

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Neutrophils, from marrow to microbes. (2010, background): “Selectins bind sialyl Lewis X carbohydrate structures expressed on their ligands (Somers et al., 2000).”
Direct observation of catch bonds involving cell-adhesion molecules (2003, background): “The crystal structure of this complex reveals a broad, shallow binding interface, but it does not readily explain how force elicits the catch–slip transitional bond features that we observe”
Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT. (2004, background): “…of macromolecular models can be found in the literature (e.g. Dessen et al., 1999; Fischmann et al., 1999; Bard et al., 2000; Koronakis et al., 2000; Somers et al., 2000; Ng et al., 2000; von Delft et al., 2001; Han et al., 2001; Vicens & Westhof, 2002; Hanzal-Bayer et al., 2002; Benach et al.,…”
Determination of network of residues that regulate allostery in protein families using sequence analysis (2006, positive): “Besides the three classes of residues, regions of the P- and E-selectins apparently undergo large conformational changes upon complexation (Somers et al., 2000).”