Series Introduction: The transcription factor NF-κB and human disease

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Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. (2002, background): “If so, ceramide activation of NF B (27) would cause upregulation of gene(s) other than the iNOS gene, which would not be surprising considering the pleiotropic effects of NF B on gene regulation (28).”
International Union of Pharmacology. XLV. Classification of the Kinin Receptor Family: from Molecular Mechanisms to Pathophysiological Consequences (2005, background): “In animal models, noxious treatments applied in vivo render subsequently isolated smooth muscle preparations immediately responsive to B1 receptor agonists (e.g., the chemical inflammation of the rat urinary bladder, the injection of a sublethal dose of LPS in the rabbit; Marceau et al., 1998).”