Applications of gold nanoparticles in cancer nanotechnology
By Weibo Cai, Ting Gao, H. Hong, Jiangtao Sun. Nanotechnology, Science and Applications, 2008
817 citations recorded by the source corpus.
It has been almost 4 decades since the “war on cancer” was declared. It is now generally believed that personalized medicine is the future for cancer patient management. Possessing unprecedented potential for early detection, accurate diagnosis, and personalized treatment of cancer, nanoparticles have been extensively studied over the last decade. In this review, we will summarize the current state-of-the-art of gold nanoparticles in biomedical applications targeting cancer. Gold nanospheres, nanorods, nanoshells, nanocages, and surface enhanced Raman scattering nanoparticles will be discussed in detail regarding their uses in in vitro assays, ex vivo and in vivo imaging, cancer therapy, and drug delivery. Multifunctionality is the key feature of nanoparticle-based agents. Targeting ligands, imaging labels, therapeutic drugs, and other functionalities can all be integrated to allow for targeted molecular imaging and molecular therapy of cancer. Big strides have been made and many proof-of-principle studies have been successfully performed. The future looks brighter than ever yet many hurdles remain to be conquered. A multifunctional platform based on gold nanoparticles, with multiple receptor targeting, multimodality imaging, and multiple therapeutic entities, holds the promise for a “magic gold bullet” against cancer.
Subfields: Biomaterials, Electronic, Optical and Magnetic Materials, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/3378e474cb60ed885e91a955c016efb44bdc7a57
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In Electronic, Optical and Magnetic Materials
Citations in the corpus
- Reviewing the Tannic Acid Mediated Synthesis of Metal Nanoparticles (2014, background): “Specifically gold nanoparticles in the 1–10 nm size range have size-tunable physicochemical properties that are useful in a wide variety of applications such as cancer diagnostics, catalysis, Raman and fluorescence spectroscopy, selective ionisation of biomolecule, water purification, drug delivery,”
- A Review of Current Research into the Biogenic Synthesis of Metal and Metal Oxide Nanoparticles via Marine Algae and Seagrasses (2017, background): “This is of particular importance since conventionally manufacturedAu nanoparticles have been used in a variety of biomedical applications such as carriers for anticancer drugs [16, 19, 129, 148], biosensors [6], and targets in tumors for thermal treatment therapies [149, 150].”