Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex.

By J. Kleim, S. Barbay, N. R. Cooper, T. M. Hogg, Chelsea N. Reidel, M. Remple, R. Nudo. 2002

533 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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Citations in the corpus

Weight Agnostic Neural Networks (2019, background): “For humans it is evident, especially during early childhood [46, 107], that we learn skills and form memories by forming new synaptic connections, and our brain rewires itself based on our new experiences [5, 11, 18, 50].”
Virtual Environments for Motor Rehabilitation: Review (2005, unknown): “Similar re-sults have been reported by Wise et al. using the same technique of single-cell recordings with a different 29 Studies by Greenough et al. 30 and Kleim et al. 31 have revealed some of the mechanisms underlying the functional reorganization in the motor cortex following motor learning.”
Imaging brain plasticity during motor skill learning. (2002, background): “Interestingly, Kleim et al. (2002) have demonstrated not only that motor learning produces changes in synaptogenesis, but also that these structural changes are colocalized to the region within which alterations in learning-dependent representational maps are observed following extended practice.”
The neurobiology of consolidations, or, how stable is the engram? (2004, background): “Multiple brain areas subserve this type of task, including among others the primary motor cortex, other neocortical areas, the cerebellar cortex and deep nuclei, and the striatum (Doyon et al. 1997, Karni et al. 1998, Kleim et al. 2002, Nudo et al. 1996, Ungerleider et al. 2002).”
Training-induced structural changes in the adult human brain. (2008, background): “One of the possible mechanisms underlying similar reorganisation processes induced by motor learning appeared to be synaptogenesis [66].”
Ankle dorsiflexion as an fMRI paradigm to assay motor control for walking during rehabilitation (2004, background): “…to motor learning (Biernaskie et al., 2004; Cramer and Chopp, 2000; Frost et al., 2003; Gomez-Pinilla et al., 2002; Johansson and Belichenko, 2002; Kleim et al., 2002; Lotze et al., 2003a; Morgen et al., 2004; Rossini et al., 2003; Schaechter and Cramer, 2003; Uy et al., 2003; van Praag et al.,…”
Activity-dependent structural plasticity. (2009, background): “Kleim et al. (2002, 2004) reported a specific enlargement of the cortical paw representation (at the expense of foreleg representation, which shrinks) associated with synapse formation after seven days of motor skill learning.”
Sensorimotor Training in Virtual Reality: A Review (2009, unknown): “Empirical data strongly emphasize that learning new motor skills is essential for inducing functional plasticity [68] [89] [101], therefore, it appears that critical variables necessary to promote functional changes and neural plasticity are the dynamic and adaptive development and formation of new…”
Cortical Synaptogenesis and Motor Map Reorganization Occur during Late, But Not Early, Phase of Motor Skill Learning (2004, background): “Furthermore, changes in cortical synapse number have been shown to be both localized to regions of motor cortex that undergo reorganization (Kleim et al., 2002b) and only detectable during the late phase (Kleim et al., 1996).”