Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome.

By G. Barbara, V. Stanghellini, R. De Giorgio, C. Cremon, G. Cottrell, D. Santini, G. Pasquinelli, A. Morselli-Labate, E. Grady, N. Bunnett and 2 more. Gastroenterology, 2004

1,453 citations recorded by the source corpus.

Subfields: Gastroenterology, Immunology, Physiology

View Paper: https://www.semanticscholar.org/paper/25bccc3b5faf67f0e9fb401a84caa2433d056c98

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Lan Lin
2. S. Bischoff
3. Takuya Suzuki
4. Jianqiong Zhang

In Physiology

1. S. Bischoff

Citations in the corpus

• Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data (2007, background): “This explains why mast cells have been found to be involved in so many different types of human disease in addition to allergic disorders, including inflammatory diseases, neurological diseases and functional diseases such as irritable bowel syndrome, functional dyspepsia and fibromyalgi”
• Role of intestinal microbiota and metabolites on gut homeostasis and human diseases (2017, background): “patients has been demonstrated to be correlated with the severity and frequency of abdominal pain [179].”
• Intestinal microbiota in functional bowel disorders: a Rome foundation report (2012, background): “Changes in these factors (eg, changes in mucus layer and increased b-defensin-2 peptide) have been detected in patients with IBS and functional diarrhoea and suggest a microbiotaehost immune system engagement.145 146 In line with this concept, there is also recent demonstration that IBS patients hav”
• Regulation of intestinal epithelial permeability by tight junctions (2012, background): “In IBS patients, the intestinal mucosa appears normal at endoscopic or conventional histologic examination, but contains a greater number of immune cells, including mast cells and T cells, indicating increased cytokine production and inflammation [280, 281].”