Mechanisms of nutritional and hormonal regulation of lipogenesis

By S. Kersten. EMBO Reports, 2001

714 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

An emerging role of mTOR in lipid biosynthesis (2009, positive): “This process, defined as de novo lipogenesis, is strongly driven by insulin (reviewed in [3]).”
Transcriptional control of adipose lipid handling by IRF4 (2011, positive): “During feeding, insulin exerts its prolipogenic functions via a transcription factor called sterol regulatory element binding protein 1c (SREBP1c), while the effects of carbohydrates and polyunsaturated fatty acids are mediated by carbohydrate response element binding protein (ChREBP) and liver X re”
Biochemistry of adipose tissue: an endocrine organ (2013, background): “Hormone-sensitive lipase is inhibited by insulin and is favored by the presence of glucagon and epinephrine [9, 10, 12].”
Insulin Resistance: From Mechanisms to Therapeutic Strategies (2021, background): “Insulin also promotes lipogenesis in white adipose tissue by activating SREBP-1c, signaling the translocations of glucose or fatty acid transport proteins (FATPs), promoting fatty acid esterification [26], and stimulating adipogenesis through the transcription factor peroxisome proliferator-activate”