The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss.

By A. Secher, J. Jelsing, Arian F. Baquero, J. Hecksher-Sørensen, M. Cowley, L. S. Dalbøge, G. Hansen, K. Grove, C. Pyke, K. Raun and 6 more. Journal of Clinical Investigation, 2014

833 citations recorded by the source corpus.

Subfields: Endocrine and Autonomic Systems, Endocrinology, Diabetes and Metabolism, Physiology

View Paper: https://www.semanticscholar.org/paper/25a76beacceb1bbb6f6d3436151a47152c14e156

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrine and Autonomic Systems

1. D. J. Drucker
2. Matthias Tschöp

In Endocrinology, Diabetes and Metabolism

1. J. Meier
2. M. Nauck
3. L. Knudsen
4. D. J. Drucker
5. F. Reimann
6. F. Gribble
7. Ralph DeFronzo
8. Josephine M. Egan

In Physiology

1. Matthias Tschöp

Citations in the corpus

• Incretin hormones: Their role in health and disease (2018, background): “The relevant GLP-1 receptors seem to be in the hypothalamus.(45) GLP-1 may enter the brain from the blood stream through circumventricular organs, which are characterized by a leaky blood–brain barrier.”
• Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1. (2018, background): “Moreover, a fluorescent liraglutide analog was detected within the ARC, PVN, supraoptic nucleus, and supraoptic decussation in both rats and mice after peripheral administration, with brain uptake dependent on a functional GLP-1R (Secher et al., GLP-1 levels rise following Roux-en-Y gastric bypass (”
• Semaglutide lowers body weight in rodents via distributed neural pathways. (2020, background): “Furthermore, the efficacy of liraglutide is not altered by area postrema (AP) or PVH ablation or by vagal lesions (8, 20).”
• GLP-1 receptor agonists in the treatment of type 2 diabetes – state-of-the-art (2020, background): “POMC/CART neurons expressing GLP-1 receptors activate PB neurons and directly or indirectly suppress NPY/AgRP neurons [72,73], leading to disinhibition of suppressive signals to the PB (Figure 6).”
• Glucagon-like peptide 1 (GLP-1) (2019, background): “While these studies suggest that GLP-1 influx into the brain might be a GLP-1R-independent process with passive diffusion of GLP-1 through the BBB [750e752], other studies suggest that uptake of liraglutide into the brain is GLP-1R-dependent [686,753].”