Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes

By Laura K. Mackay, M. Minnich, Natasja A M Kragten, Yang Liao, B. Nota, Cyril Seillet, Ali Zaid, K. Man, Simon P. Preston, D. Freestone and 15 more. Science, 2016

909 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/25222f9807925c2e4e7c3153bfeaa1e1b919f310

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. J. Seita
2. Miriam Merad
3. Brahma V. Kumar
4. Judy H. Cho
5. Irving L. Weissman
6. D. Farber

In Molecular Biology

1. Eric E. Schadt
2. Irving L. Weissman
3. Stephen R. Quake
4. Austin G Smith
5. Hans Clevers
6. Daniel J. Garry
7. T. Hawke
8. M. Clarke

Citations in the corpus

• Human T cell development, localization, and function throughout life (2018, background): “In mice, the transcription factor Hobit is exclusively expressed by and required for the development of Trm cells following infection (Mackay et al., 2016), while in humans, Trm phenotype cells express low-tonegligible levels of Hobit transcripts (Kumar et al.”
• Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites (2017, methodology): “…core transcriptional profile common to CD69+ memory T cells in spleen and lungs defined a TRM signature, we compared the RNA-seq profile of the human tissue and blood subsets with that of mouse antigen-specific CD8+ TRMs isolated from skin and intestines following infection (Mackay et al., 2016).”
• A molecular cell atlas of the human lung from single cell RNA sequencing (2019, background): “The 58 identified cell populations included 15 epithelial (clusters 1-15), 9 endothelial (16-24), 9 stromal (25-33), and 25 immune (34-58) populations, greater than the number of classical cell types in each compartment (11 epithelial, 5 endothelial, 7 stromal, 20 immune, and 2 neuronal cell types) ”
• Single-Cell Analysis of Crohn’s Disease Lesions Identifies a Pathogenic Cellular Module Associated with Resistance to Anti-TNF Therapy (2019, background): “Two of these clusters were highly enriched for the cytotoxic program (#26, 4), thus reminiscent of the Trm poised for cytotoxic functions recently described in the skin (Cheuk et al., 2017).”