PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

By Vamsi K. Mootha, C. Lindgren, K. Eriksson, Aravind Subramanian, S. Sihag, Joseph Lehar, P. Puigserver, E. Carlsson, M. Ridderstråle, E. Laurila and 11 more. Nature Genetics, 2003

8,321 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

GENOMIC DATA ANALYSIS (2004, methodology): “A different approach, termed gene set enrichment analysis (GSEA), is presented by Mootha et al. (2003).”
A major chromatin regulator determines resistance of tumor cells to T cell–mediated killing (2018, methodology): “jsp) was used to calculate the overlap between a gene list and pathways in MSIgDB (Molecular signature database) (48, 49).”
The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques (2019, result): “The numbers in the bars indicate the size of the GSEA-predicted leading edge (core enrichment genes), which can be interpreted as the genes responsible for the observed enrichment.”
Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure (2013, background): “A key component dictating the efficiency of mitochondrial quality control by fusion, fission, and autophagy is the ability of a full cycle to be completed and the number of cycles per day (Mouli et al., 2009).”