Pathogenesis of Human Papillomaviruses in Differentiating Epithelia

By Michelle S. Longworth, L. Laimins. Microbiology and Molecular Biology Reviews, 2004

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Chapter 1: HPV in the etiology of human cancer. (2006, background): “There are differences between the E6/E7 proteins f high-risk and low-risk HPV types, but these are often of quantitative rather than a qualitative nature [4].”
Redefining chronic viral infection. (2009, neutral): “transcriptional programs as skin cells differentiate and move toward the body surface, eventually resulting in shedding of a metabolically dead cell-husk filled with infectious virus (Longworth and Laimins, 2004).”
Intrinsic disorder and functional proteomics. (2007, background): “These viruses have a circular double stranded DNA genome of ;8 kb that encode eight to nine proteins, including six nonstructural proteins [E1, E2, E4, E5, E6 and E7 (the latter two are known to function as oncoproteins in the high-risk HPVs)] and two structural proteins (L1, and L2) (145,146,148).”