History of myeloid derived suppressor cells (MDSCs) in the macro- and micro-environment of tumour-bearing hosts

By J. Talmadge, D. Gabrilovich. Nature Reviews. Cancer, 2013

1,128 citations recorded by the source corpus.

Tumour-induced granulocytic hyperplasia is associated with tumour vasculogenesis and escape from immunity via T cell suppression. Initially, these myeloid cells were identified as granulocytes or monocytes; however, recent studies have revealed that this hyperplasia is associated with populations of multipotent progenitor cells that have been identified as myeloid-derived suppressor cells (MDSCs). The study of MDSCs has provided a wealth of information regarding tumour pathobiology, has extended our understanding of neoplastic progression and has modified our approaches to immune adjuvant therapy. In this Timeline article, we discuss the history of MDSCs, their influence on tumour progression and metastasis, and the crosstalk between tumour cells, MDSCs and the host macroenvironment.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/24f56c0e51cbe21dfef002bed3237ce533fe6bd0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. D. Marvel
2. R. DePinho
3. Guocan Wang
4. Di Zhao
5. D. Spring
6. D. Gabrilovich
7. V. Bronte
8. J. Massagué

In Oncology

1. D. Gabrilovich
2. R. DePinho

Citations in the corpus

• Genetics and biology of prostate cancer (2018, background): “MDSCs were initially defined in murinemodels by the coexpression of CD11b andGr-1markers (Bronte et al. 1998; Talmadge and Gabrilovich 2013) and can be further separated into granulocytic MDSCs (CD11b+Ly6G+) and monocytic MDSCs (M-MDSCs; CD11b+Ly6C+).”
• Myeloid-derived suppressor cells (2017, background): “org Cancer Immunol Res; 5(1) January 2017 5”
• Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected. (2015, background): “This subject has been recently reviewed (6, 7).”
• Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives (2021, background): “MDSCs mainly contain two cell subsets, termed polymorphonuclear MDSCs (PMN-MDSCs) and monocytic MDSCs (M-MDSCs), which are phenotypically and morphologically similar to neutrophils and monocytes, respectively [235, 236].”