Repair of O6-alkylguanine by alkyltransferases

By A. E. Pegg. 2000

512 citations recorded by the source corpus.

Subfields: Molecular Biology, Rheumatology

View Paper: https://www.semanticscholar.org/paper/24e4e7439a60d6dc1acf3d1ce4520f5cf7de60fc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. H. Ohgaki
2. P. Kleihues
3. Rune Forstrøm Johansen
4. Erling Seeberg
5. Stanton L. Gerson
6. P. Falnes
7. Sean R. Eddy

In Rheumatology

1. Rune Forstrøm Johansen
2. Erling Seeberg
3. H. Ohgaki
4. Stanton L. Gerson
5. P. Kleihues
6. P. Falnes

Citations in the corpus

• Genetic pathways to primary and secondary glioblastoma. (2007, background): “Various adducts at this position are substrates for repair by MGMT.(82) Such adducts typically result from exposure to N-nitrosamides and related alkylating agents that cause brain tumors in rats,(83) but there is currently no evidence indicating that alkylating carcinogens are involved in the etiol”
• Alkylation damage in DNA and RNA--repair mechanisms and medical significance. (2004, background): “AGT prefers lesions in double-stranded B-DNA and repair Z-DNA, DNA:RNA hybrids and single-stranded DNA more slowly (reviewed in[54]).”
• AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli (2002, methodology): “In the transferase reaction the alkyl group is transferred from the DNA to the transferase itself, which is then consumed during repair in a stoichiometric fashion (reviewed in ref”
• MGMT promoter methylation in malignant gliomas: ready for personalized medicine? (2010, background): “MGMT rapidly reverses alkylation, including methylation, at the O(6) position of guanine by transferring the alkyl group to the active site of the enzyme.(3) Although O(6)-alkylguanine is not the main lesion induced by alkylating agents, it seems to be the most cytotoxic one.”
• Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. (2005, background): “DNA methylation may be caused by N-nitroso compounds in food or tobacco (21, 64), and through nonenzymatic methylation by S-adenosylmethionine (SAM) (65).”
• MGMT: its role in cancer aetiology and cancer therapeutics (2004, background): “AGT repairs O 6 -AG in both open chromatin during transcription and replication, and in resting, condensed DN”