Lymphocyte Cc Chemokine Receptor 9 and Epithelial Thymus-Expressed Chemokine (Teck) Expression Distinguish the Small Intestinal Immune Compartment

By Eric J. Kunkel, J. Campbell, G. Haraldsen, Junliang Pan, Judie Boisvert, A. Roberts, E. Ebert, Mark A. Vierra, S. Goodman, M. Genovese and 6 more. Journal of Experimental Medicine, 2000

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The immune system has evolved specialized cellular and molecular mechanisms for targeting and regulating immune responses at epithelial surfaces. Here we show that small intestinal intraepithelial lymphocytes and lamina propria lymphocytes migrate to thymus-expressed chemokine (TECK). This attraction is mediated by CC chemokine receptor (CCR)9, a chemoattractant receptor expressed at high levels by essentially all CD4+ and CD8+ T lymphocytes in the small intestine. Only a small subset of lymphocytes in the colon are CCR9+, and lymphocytes from other tissues including tonsils, lung, inflamed liver, normal or inflamed skin, inflamed synovium and synovial fluid, breast milk, and seminal fluid are universally CCR9−. TECK expression is also restricted to the small intestine: immunohistochemistry reveals that intense anti-TECK reactivity characterizes crypt epithelium in the jejunum and ileum, but not in other epithelia of the digestive tract (including stomach and colon), skin, lung, or salivary gland. These results imply a restricted role for lymphocyte CCR9 and its ligand TECK in the small intestine, and provide the first evidence for distinctive mechanisms of lymphocyte recruitment that may permit functional specialization of immune responses in different segments of the gastrointestinal tract. Selective expression of chemokines by differentiated epithelium may represent an important mechanism for targeting and specialization of immune responses.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/24c204265dea4c145e89fa7170b456fb00740bc5

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Citations in the corpus

Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire1 (2001, background): “CCR9 is expressed only on a subset of a4b7 integrin-expressing memory CD4 cells, which home preferentially through mucosal tissues (26).”
Chemokines and chemokine receptors in leukocyte trafficking. (2002, neutral): “LARC is expressed by cells comprising the villous epithelium , but not by crypt cells , whereas TECK is expressed in the opposite pattern ( 99 , 174 ) .”
Dynamic T cell migration program provides resident memory within intestinal epithelium (2010, background): “We next tested whether memory CD8 T cells in mucosal tissues also lacked  4  7, and we determined the dynamics of CCR9 expression, which is also involved in migration to gut (Zabel et al., 1999; Kunkel et al., 2000; Johansson-Lindbom T splenocytes and is then rapidly down-regulated.”