Quantitative mapping of amplicon structure by array CGH identifies CYP24 as a candidate oncogene

By Donna Albertson, Bauke Ylstra, R. Segraves, Colin C. Collins, S. Dairkee, D. Kowbel, W. Kuo, Joe W. Gray, Dan Pinkel. Nature Genetics, 2000

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Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. (2016, background): “2, which contains the CYP24A1 gene, was found to be amplified (13).”
Noncalcemic actions of vitamin D receptor ligands. (2005, background): “Because 24-hydroxylase is involved in 1,25-(OH)2D3 degradation, its amplification may lead to decreased serum 1,25-(OH)2D3 levels, thus providing a microenvironment conducive for cell growth in the absence of vitamin D-mediated growth control (198).”
Vitamin D and human health: lessons from vitamin D receptor null mice. (2008, background): “2, which contains the CYP24A1 gene, was found to be amplified in breast tumors (35).”
Development of query strategies to identify a histologic lymphoma subtype in a large linked database system. (2006, neutral): “Historically, arrays were designed to cover speci ﬁ c chromosomes (Buckley et al. 2002; Buckley et al. 2005), chromosome arms (Coe et al. 2005; Garnis et al. 2003; Henderson et al. 2005) or selected regions of the genome implicated in disease (Albertson et al. 2000; Schwaenen et al. 2004).”