A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis

By K. Andries, P. Verhasselt, J. Guillemont, Hinrich W. H. Göhlmann, Jean-Marc Neefs, H. Winkler, J. van Gestel, P. Timmerman, Min Zhu, Ennis Lee and 8 more. Science, 2005

2,133 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/23e733a5c3c8dd8f3976f4151b287506fa2d1813

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. Stefan Niemann
2. C. Walsh
3. Michal Feldman
4. James J. Collins
5. Elaine R. Mardis
6. Michael A. Fischbach

In Molecular Biology

1. Pavel A. Pevzner
2. James J. Collins
3. Mark J. P. Chaisson
4. Ahmad S. Khalil
5. Michael A. Fischbach
6. Graham F. Hatfull
7. Carlos A. Guerrero-Bustamante
8. R. Dedrick

Citations in the corpus

• Toward a Phage Cocktail for Tuberculosis: Susceptibility and Tuberculocidal Action of Mycobacteriophages against Diverse Mycobacterium tuberculosis Strains (2021, background): “New antibiotics, including bedaquiline (7), have been developed, but the”
• Drugs for bad bugs: confronting the challenges of antibacterial discovery (2007, background): “pneumoniae to the atpC subunit of theF 0 F 1 ATPase, a target limited in essentiality to selected pathogens including some streptococci and Mycobacterium tuberculosis”
• The impact of next-generation sequencing technology on genetics. (2008, background): “A remarkable study by an international consortium used 454 sequencing of Mycobacterium tuberculosis to identify drug targets of a diarylquinoline drug that potently inhibited both drugsensitive and -resistant strains of the pathogen [ 21 ].”
• Short read fragment assembly of bacterial genomes. (2008, background): “The applications of HTSR sequencing have been largely limited, albeit with great success, to resequencing (Andries et al. 2005), gene expression (Kim et al.”
• High Functional Diversity in Mycobacterium tuberculosis Driven by Genetic Drift and Human Demography (2008, background): “], as well as genes of special interest, including putative new drug targets [”
• The diarylquinoline TMC207 for multidrug-resistant tuberculosis. (2009, neutral): “Unilateral 3 (13) 5 (21) Bilateral 2 ( 9 ) 3 (12)”
• The spectrum of latent tuberculosis: rethinking the goals of prophylaxis (2009, neutral): “Subsequent identification of the mechanism of action of active compounds is achieved by sequencing the genome of spontaneous drug-resistant mutant”