Functions of Polyamines in Mammals*
By A. E. Pegg. Journal of Biological Chemistry, 2016
594 citations recorded by the source corpus.
The content of spermidine and spermine in mammalian cells has important roles in protein and nucleic acid synthesis and structure, protection from oxidative damage, activity of ion channels, cell proliferation, differentiation, and apoptosis. Spermidine is essential for viability and acts as the precursor of hypusine, a post-translational addition to eIF5A allowing the translation of mRNAs encoding proteins containing polyproline tracts. Studies with Gy mice and human patients with the very rare X-linked genetic condition Snyder-Robinson syndrome that both lack spermine synthase show clearly that the correct spermine:spermidine ratio is critical for normal growth and development.
Subfields: Biochemistry, Immunology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/fa178be64a4906ab9423e8135b7a1423c95dce97
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Citations in the corpus
- Polyamine Function in Plants: Metabolism, Regulation on Development, and Roles in Abiotic Stress Responses (2019, background): “This is the main Put synthesis pathway in plants (Docimo et al., 2012; Pegg, 2016).”
- Spermidine in health and disease (2018, background): “1) in tightly regulated step-wise reactions (20, 22, 29).”
- ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells (2019, background): “They are involved in protein posttranslational modifications, regulation of ion channels, maintenance of nucleic acid, and protein structure and stability, as well as cell-cell communications [93].”