Regulation of SIRT1 in cellular functions: role of polyphenols
By Sangwoon Chung, H. Yao, S. Caito, Jae-woong Hwang, Gnanapragasam Arunachalam, I. Rahman. Archives of Biochemistry and Biophysics, 2010
661 citations recorded by the source corpus.
Sirtuin 1 (SIRT1) is known to deacetylate histones and non-histone proteins including transcription factors thereby regulating metabolism, stress resistance, cellular survival, cellular senescence/aging, inflammation-immune function, and endothelial functions, and circadian rhythms. Naturally occurring dietary polyphenols, such as resveratrol, curcumin, quercetin, and catechins, have antioxidant and anti-inflammatory properties via modulating different pathways, such as NF-κB- and mitogen activated protein kinase-dependent signaling pathways. In addition, these polyphenols have also been shown to activate SIRT1 directly or indirectly in a variety of models. Therefore, activation of SIRT1 by polyphenols is beneficial for regulation of calorie restriction, oxidative stress, inflammation, cellular senescence, autophagy/apoptosis, autoimmunity, metabolism, adipogenesis, circadian rhythm, skeletal muscle function, mitochondria biogenesis and endothelial dysfunction. In this review, we describe the regulation of SIRT1 by dietary polyphenols in various cellular functions in response to environmental and pro-inflammatory stimuli.
Subfields: Geriatrics and Gerontology, Physiology
View Paper: https://www.semanticscholar.org/paper/238e5db8107195f1f32133493fe3bb13dcb0a5da
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In Geriatrics and Gerontology
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Citations in the corpus
- Immune System Dysregulation During Spaceflight: Potential Countermeasures for Deep Space Exploration Missions (2018, background): “, resveratrol, quercetin, catechins, and curcumin), have antioxidant and anti-inflammatory benefits (51).”
- AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan (2011, background): “Several dietary polyphenols can activate AMPK and SIRT1, and it seems that their antiinflammatory effects are mediated via the AMPK/SIRT1induced p65 deacetylation [56].”
- Resources and Biological Activities of Natural Polyphenols (2014, neutral): “many tissues, including myocardium [65,66].”
- Anti-apoptosis and cell survival: a review. (2011, background): “The fact that SIRT1 can prevent apoptosis while other mammalian anti-apoptotic genes may serve to extend lifespan also strengthens the concept that aging mediated cell death is likely a programmed cell death involving the apoptotic or necrotic machinery [56,234,235].”
- The therapeutic potential of resveratrol: a review of clinical trials (2017, background): “Caloric restriction activates the deacetylases sirtuins, most notably SIRT1, which is also activated by resveratrol.(7) While clinical studies on the effects of resveratrol in AD remain scarce, two phase 2 clinical trials have shown that resveratrol is safe to use in patients with mild to moderate A”