Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers.
By M. Dreher, Wenge Liu, C. Michelich, Mark W. Dewhirst, F. Yuan, A. Chilkoti. Journal of the National Cancer Institute, 2006
896 citations recorded by the source corpus.
Subfields: Biomaterials, Biomedical Engineering, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/236aad6398f47b3e0fb11dae9b22c55fc9cedf5f
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Citations in the corpus
- Investigating the optimal size of anticancer nanomedicine (2014, background): “Macromolecules of relatively low molecular masses (<40,000 Da and <10 nm) were also shown to have low overall tumor retention because of both rapid permeation into and clearance from tumor tissues, behaving to some extent like small molecule drugs (18, 19).”
- Interstitial flow and its effects in soft tissues. (2007, background): “Tumors often have leaky vessels and nonfunctional internal lymphatics (30), which in turn leads to exudation and accumulation of large quantities of macromolecules, a phenomenon known as enhanced permeability and retention (EPR) (117, 118).”
- Nanomedicine for drug delivery and imaging: A promising avenue for cancer therapy and diagnosis using targeted functional nanoparticles (2007, background): “In contrast to normal tissue, tumors contain a high density of abnormal blood vessels that are dilated and poorly differentiated, with a chaotic architecture and aberrant branching.(27,28) Subsequently, various functions of the tumor vasculature were found to be impaired; these impaired functions ac”
- The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery (2011, background): “and retention in the SLN as discussed below [6,45,46].”
- Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles (2009, background): “Passive tumor targeting takes advantage of the irregularity and leakiness of tumor vasculature to allow nanoparticle accumulation in the tumor (caused by the enhanced permeability and retention effect) (2, 3).”
- Nanoparticle-based drug delivery systems: a commercial and regulatory outlook as the field matures (2017, methodology): “The design of effective targeted drug delivery system requires a good understanding of endocytosis trafficking pathways, the optimization of ligand density, as well as an adequate analytical method for the quantification of ligand density on particle surface [41,42].”
- Visualizing stromal cell dynamics in different tumor microenvironments by spinning disk confocal microscopy (2008, positive): “Pioneering studies have established intravital imaging techniques for analyzing cell dynamics within the tissues of live mice, including within tumors (Brown et al., 2001; Jain et al., 2002; Brown et al., 2003; Halin et al., 2005; Hoffman, 2005; Stroh et al., 2005; Dreher et al., 2006; Sidani et al.”
- Nanoparticle therapeutics: an emerging treatment modality for cancer (2008, background): “However, large macromolecules or nanoparticles could have limited diffusion in the extracellular spac”
- Stimuli-responsive clustered nanoparticles for improved tumor penetration and therapeutic efficacy (2016, background): “Angew Chem Int Ed Engl 52(24):6218–6221.”
- A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics (2012, neutral): “These observed behaviors are attributed to the effective interstitial diffusion coefficient, which decreases as the molecular weight of the diffusing molecule increases (Dreher et al., 2006).”