Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of…
By J. A. Mengshol, Matthew P. Vincenti, C. I. Coon, A. Barchowsky, C. Brinckerhoff. Arthritis & Rheumatism, 2000
661 citations recorded by the source corpus.
Subfields: Cancer Research, Molecular Biology, Rheumatology
View Paper: https://www.semanticscholar.org/paper/23545c714af62bf1e02ba6411a7e60983e7eed78
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Citations in the corpus
- Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors (2001, methodology): “chondrocytes rely on the p38, JNK and NF-κB pathways to activate MMP-13 [ 7 ].”
- NF-kappaB: a key role in inflammatory diseases. (2001, positive): “For instance, NF-κB translocation can enhance transcription of the collagenase-3 (MMP13) gene in IL-1–stimulated synoviocytes (27).”
- Synovial fibroblasts: key players in rheumatoid arthritis. (2006, background): “In addition, some of theMMP promoter sites contain binding sites for NF B [46, 47] and signal transduction and activation of transcription (STAT) [48].”
- Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis: A Randomized Clinical Trial (2017, result): “Suppression of inflammation could attenuate catabolic effects of inflammation and reduce articular damage.(35) However, these results showed greater progression of knee cartilage volume loss”
- The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis (2014, background): “In addition to the decrease in the synthesis of the building blocks, the IL-1β affects the operation of chondrocytes in the synthesis of enzymes from the group ofmetalloproteinases (MMPs),mainly interstitial collagenase (MMP-1), stromelysin-1 (MMP-3), and collagenase 3 (MMP13), which have a destruct”
- The Role of Synovitis in Osteoarthritis pathogenesis (2012, background): “IL-1β signaling suppresses aggrecan [83] and collagen synthesis [37] in chondrocytes, and also can up-regulate the proteolytic enzymes ADAMTS-4 [108] and MMP-13 [71].”