Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease

By Pavan K. Auluck, H. Chan, John Q. Trojanowski, V. Lee, N. Bonini. Science, 2001

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Different Species of α-Synuclein Oligomers Induce Calcium Influx and Seeding (2007, background): “…rather than mature fibrils of -syn, are the pathogenic species (Conway et al., 2000; Goldberg and Lansbury, 2000; Masliah et al., 2000; Auluck et al., 2002; Bucciantini et al., 2002, 2004; Gosavi et al., 2002; Kayed et al., 2003, 2004; Park and Lansbury, 2003; Bodner et al., 2006;…”
Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase. (2003, methodology): “decarboxylase (Ddc) gene has been used recently to study dopaminergic cell degeneration in a fly model of Parkinson disease (Feany and Bender, 2000; Auluck et al., 2002 ).”
Modulation of neurodegeneration by molecular chaperones (2005, background): “Recent studies in Drosophila melanogaster indicate that HSP70 might have a protective role in P”