Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element.

By E. Balogun, M. Hoque, P. Gong, E. Killeen, C. Green, R. Foresti, J. Alam, R. Motterlini. Biochemical Journal, 2003

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How Do Nutritional Antioxidants Really Work: Nucleophilic Tone and Para-Hormesis Versus Free Radical Scavenging in vivo (2013, positive): “Other phytochemicals including curcumin from turmeric [129], diallyl sulfide from garlic [130], and resveratrol from grapes [131], activate Nrf2 through direct conjugation with the reactive cysteine of Keap1.”
The emerging role of the Nrf2–Keap1 signaling pathway in cancer (2013, background): “Curcumin is another well-investigated chemopreventive natural product that is capable of activating Nrf2 (Balogun et al. 2003).”
Nrf2 as a Master Redox Switch in Turning on the Cellular Signaling Involved in the Induction of Cytoprotective Genes by Some Chemopreventive Phytochemicals (2008, positive): “Balogun et al. [74] reported that curcumin disrupted the Nrf2-Keap1 complex, leading to increased Nrf2 binding to ARE and subsequent increases in the expression and the activity of HO-1 in porcine renal epithelial proximal tubule (LLC-PK 1 ) cells and/ or rat kidney epithelial (NRK-52E) cells via…”
Targets of curcumin (2011, background): “Nrf2 activation by curcumin has been linked to the induction of hemeoxygenase-1 (HO-1), and the increase in the expression and the promoter activity of the aldose reductase [59,60].”