Guidelines and definitions for research on epithelial–mesenchymal transition
By Jing Yang, P. Antin, G. Berx, C. Blanpain, Thomas Brabletz, M. Bronner, Kyra Campbell, A. Cano, J. Casanova, Gerhard Christofori and 37 more. Nature reviews. Molecular cell biology, 2020
1,774 citations recorded by the source corpus.
Epithelial–mesenchymal transition (EMT) encompasses dynamic changes in cellular organization from epithelial to mesenchymal phenotypes, which leads to functional changes in cell migration and invasion. EMT occurs in a diverse range of physiological and pathological conditions and is driven by a conserved set of inducing signals, transcriptional regulators and downstream effectors. With over 5,700 publications indexed by Web of Science in 2019 alone, research on EMT is expanding rapidly. This growing interest warrants the need for a consensus among researchers when referring to and undertaking research on EMT. This Consensus Statement, mediated by ‘the EMT International Association’ (TEMTIA), is the outcome of a 2-year-long discussion among EMT researchers and aims to both clarify the nomenclature and provide definitions and guidelines for EMT research in future publications. We trust that these guidelines will help to reduce misunderstanding and misinterpretation of research data generated in various experimental models and to promote cross-disciplinary collaboration to identify and address key open questions in this research field. While recognizing the importance of maintaining diversity in experimental approaches and conceptual frameworks, we emphasize that lasting contributions of EMT research to increasing our understanding of developmental processes and combatting cancer and other diseases depend on the adoption of a unified terminology to describe EMT. In this Consensus Statement, the authors (on behalf of the EMT International Association) propose guidelines to define epithelial–mesenchymal transition, its phenotypic plasticity and the associated multiple intermediate epithelial–mesenchymal cell states. Clarification of nomenclature and definitions will help reduce misinterpretation of research data generated in different experimental model systems and promote cross-disciplinary collaboration.
Subfields: Molecular Biology, Oncology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/22a8e7bf9152ae0506a04bd1cf56c90e5c52d539
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Citations in the corpus
- The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis (2022, background): “Circulating tumor cells represent a heterogeneous group, and the various hybrid phenotypes of EMT from the epithelium (E) to mesenchyme (M) play significant roles in tumor heterogeneity [13, 199].”
- Dynamic EMT: a multi‐tool for tumor progression (2021, neutral): “The process is rather gradual and often remains incomplete, termed partial or hybrid EMT (Nieto et al , 2016; Pastushenko & Blanpain, 2019; Yang et al , 2020) (Fig 1B).”
- PI3K/Akt/mTOR Pathway and Its Role in Cancer Therapeutics: Are We Making Headway? (2022, background): “EMTlike processes play a significant role in tumor growth and malignant transformation, causing cancer cells to become more aggressive and spread (71, 72).”