Bile acid receptors as targets for drug development

By F. Schaap, M. Trauner, P. Jansen. Nature Reviews Gastroenterology &Hepatology, 2014

659 citations recorded by the source corpus.

Subfields: Oncology, Pharmacology, Surgery

View Paper: https://www.semanticscholar.org/paper/22825d3b1eb99fd1312c2b12ee6e82fb612034e7

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In Oncology

1. Tiangang Li
2. J. Y. Chiang
3. A. Chait
4. Laura J. den Hartigh
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1. G. Svegliati-Baroni
2. J. Y. Chiang
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Citations in the corpus

• Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. (2016, background): “Increasing evidence has shown that activation of BA-mediated signaling is an attractive strategy for preventing inflammatory and metabolic disorders, although the mechanisms are not fully understood (Schaap et al., 2014).”
• EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis. (2017, positive): “Obeticholic acid FXR is a nuclear ‘ligand-activated’ receptor abundantly expressed in tissues involved in the enterohepatic circulation of bile acids [4,128,21,129].”
• Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease (2020, background): “Bile acids produced by the liver facilitate the absorption of dietary fat in the small intestine, and are known to regulate lipid and glucose metabolism through the FXR (690, 691).”
• Bile Acid Signaling in Metabolic Disease and Drug Therapy (2014, background): “GLP-1 stimulates insulin secretion from the pancreas and improves insulin sensitivity, whereas FGF19 stimulates glycogen synthesis in hepatocytes and reduces serum glucose (Kir et al., 2011; Schaap et al., 2014).”
• Lipotoxicity and the gut-liver axis in NASH pathogenesis. (2018, background): “are involved in the absorption of lipids and in the bile salt-dependent flow regulation [131].”
• Altered Bile Acid Profile Associates with Cognitive Impairment in Alzheimer’s Disease – An Emerging Role for Gut Microbiome (2018, background): “It is of interest that BAs are ligands for nuclear receptors including FXR, LXRs among others and they acts synergistically as metabolic sensors to regulate energy homeostasis [73,74] peripherally and might also propagate their effects to the brain.”