Asthma: defining of the persistent adult phenotypes.
By Sally E. Wenzel. The Lancet, 2006
1,074 citations recorded by the source corpus.
Subfields: Pediatrics, Perinatology and Child Health, Physiology, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/228204aec34cdae3f36bce4bcc9a82a3b4b1e17e
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In Pediatrics, Perinatology and Child Health
In Physiology
In Pulmonary and Respiratory Medicine
Citations in the corpus
- An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. (2009, background): “There is increasing awareness in the literature and in clinical practice of the importance of different asthma phenotypes and their differences in responsiveness to treatment (58, 59).”
- Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. (2010, neutral): “Asthma is a clinical syndrome that is characterized by variability in disease expression and severity (4, 5, 11).”
- Allergic Rhinitis and its Impact on Asthma (ARIA): achievements in 10 years and future needs. (2012, background): “Heterogeneity also exists within each dimension of the disease (eg, eosinophils and asthma severity),(64) across diseases (eg, eosinophils in asthma), and in relation to comorbidities.(65) Phenotypes can change over time, possibly driven by allergic, infectious, or other triggers (PreDicta, http://w”
- T-helper type 2-driven inflammation defines major subphenotypes of asthma. (2009, background): “Our data suggest that Th2-driven inflammation is the molecular mechanism underlying the cellular phenotype of asthma known as ‘‘eosinophilic asthma’’ (28) because of the airway eosinophilia that we demonstrate in Th2-high asthma and because eosinophilic asthma and Th2-high asthma are characterized b”
- The Rotterdam Study: 2010 objectives and design update (2007, background): “Although the onset of asthma is most common during childhood, asthma can also occur in adulthood [294].”
- Immunology of asthma and chronic obstructive pulmonary disease (2008, background): “Most patients with asthma are atopic (extrinsic asthma), but a few patients are non-atopic (intrinsic asthma), and these patients often have a more severe form of the diseas”
- Cluster Analysis and Clinical Asthma Phenotypes (2008, background): “A robust system of classification that incorporates the multidimensionality of asthma is needed to identify subgroups with consistent patterns of disease (3, 4 ). This may provide a framework for identifying distinct phenotypes, with specific pathophysiologic abnormalities that predict response to ”