An SCN9A channelopathy causes congenital inability to experience pain

By J. Cox, F. Reimann, A. Nicholas, G. Thornton, E. Roberts, K. Springell, G. Karbani, H. Jafri, Jovaria Mannan, Y. Raashid and 9 more. Nature, 2006

1,590 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/22790c3f02f934eecd6984f982ed80b6a4d9c42b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Clifford J. Woolf
2. Jie Zheng
3. M. Trudeau
4. R. Baron
5. M. Malcangio
6. J. Scholz
7. Jose M. Duarte
8. William A. Catterall

In Physiology

1. Clifford J. Woolf
2. R. Baron
3. J. Scholz
4. M. Malcangio
5. Christian A. von Hehn
6. M. Costigan
7. Jie Zheng
8. L. Dvorakova

In Sensory Systems

1. Jie Zheng
2. William A. Catterall
3. Christian A. von Hehn
4. R. Baron
5. Clifford J. Woolf
6. M. Trudeau

Citations in the corpus

• The role of glia in the spinal cord in neuropathic and inflammatory pain. (2015, background): “Evidence for the importance of acute pain is provided by individuals expressing the rare phenotype of insensitivity to pain; these patients experience regular inadvertent self-mutilation through injury and have a significantly lower than average life expectancy (Cox et al. 2006; Verpoorten et al. 20”
• Neuropathic Pain (2009, background): “Loss of nociception, as in hereditary disorders associated with congenital insensitivity to pain (Cox et al. 2006, Indo 2001), leads to repeated injury and inadvertent self mutilation, illustrating the highly adaptive function of nociceptive pain.”
• RCSB Protein Data Bank: Enabling biomedical research and drug discovery (2019, background): “In 2006, a loss-of-function mutation was identified in several Pakistani street performers, who show no sensitivity to pain while walking on hot coals, and so forth.(55) Selectivity remains an elusive challenge in this arena.”
• Methods Used to Evaluate Pain Behaviors in Rodents (2017, background): “The protective role of pain is most evident in individuals who have congenital insensitivity to pain, a rare genetic condition that results in the inability to sense tissue damaging or nociceptive stimuli (Cox et al., 2006).”
• Principles of early drug discovery (2011, background): “7, both mutations incur a pain phenotype, insensitivity or oversensitivity respectively (Yang et al., 2004; Cox et al., 2006).”
• Voltage‐gated sodium channels at 60: structure, function and pathophysiology (2012, background): “7 channels cause complete loss of pain sensation (Cox et al. 2006).”
• Deconstructing the Neuropathic Pain Phenotype to Reveal Neural Mechanisms (2012, positive): “7 that result in ectopic firing of C-fibers in the absence of nerve injury and spontaneous pain conditions (Cox et al., 2006; Dib-Hajj et al., 2010; Faber et al., 2011).”
• Handbook of ion channels (2015, background): “after breaking bones or during childbirth (2,50).”