Autophagy regulates adipose mass and differentiation in mice.
By Rajat Singh, Youqing Xiang, Yongjun Wang, Kiran Baikati, A. Cuervo, Y. Luu, Yan Tang, J. Pessin, G. Schwartz, M. Czaja. Journal of Clinical Investigation, 2009
776 citations recorded by the source corpus.
Subfields: Epidemiology, Physiology
View Paper: https://www.semanticscholar.org/paper/226c4be0c89caffbeafbf9cf5fa2c0491eb655a4
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Epidemiology
- Alec C. Kimmelman
- Beth Levine
- N. Mizushima
- Jennifer Lippincott-Schwartz
- Angelika S. Rambold
- D. Klionsky
- Sarah Cohen
- N. Divecha
In Physiology
- Alec C. Kimmelman
- Beth Levine
- N. Mizushima
- Jennifer Lippincott-Schwartz
- Lewis C. Cantley
- J. Asara
- I. Slaninová
- Guido Kroemer
Citations in the corpus
- Autophagy in mammalian development and differentiation (2010, background): “The knockdown of Atg7 or Atg5 in 3T3-L1 preadipocytes also suppresses triglyceride accumulation and decreases protein levels of mediators and markers of adipocyte differentatio”
- Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease (2010, neutral): “There is also evidence that autophagy is selectively involved in the delivery of lipid droplets for lysosomal degradation (Singh et al., 2009a).”
- Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase (2011, neutral): “However, increased LD delivery to lysosomes has been shown to occur in response to starvation aswell as triglyceride loading in hepatocytes (Singh et al., 2009a).”
- Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy and mitochondrial fusion dynamics (2015, background): “…cell types might differentially utilize lipases versus lipophagy for their response to starvation; for example, release of FAs from LDs by autophagy might be of particular importance in cell types with low lipase activity, such as hepatocytes (Singh et al., 2009a; Walther and Farese, 2012).”
- Phosphatidylinositol-5-phosphate 4-kinases regulate cellular lipid metabolism by facilitating autophagy (2018, result): “While the decrease in lipid content observed in the ppk-2 mutant animals is opposite of what is seen in the PI5P4K deleted livers of nutrient starved mice, this finding is consistent with models of defective autophagy in non-hepatic tissues (Singh et al., 2009b; (Zhang et al., 2009).”