A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells

By K. Miyamoto, S. Miyake, T. Yamamura. Nature, 2001

907 citations recorded by the source corpus.

Subfields: Hematology, Immunology

View Paper: https://www.semanticscholar.org/paper/21eceb521502374cab4ac70325cb79e19313d205

How researchers see this paper

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In Hematology

1. M. Kronenberg
2. Roland Martin
3. M. Sospedra

In Immunology

1. M. Kronenberg
2. D. Godfrey
3. A. Bendelac
4. L. Teyton
5. L. Gapin
6. K. Hoebe
7. B. Beutler
8. P. Savage

Citations in the corpus

• The unconventional lifestyle of NKT cells (2002, background): “T H 2-polarized responses have been observed after the culture of total spleen cells with an analogue of α-GalCer that has one aliphatic chain that is reduced in lengt”
• Distinct Functional Lineages of Human Vα24 Natural Killer T Cells (2002, background): “It is possible that other subsets or alternative mechanisms, such as altered glycolipid ligand (13) or NK receptor signaling (14), could account for the control of Th function in these conditions.”
• The crystal structure of human CD1d with and without α-galactosylceramide (2005, background): “It has been proposed that the high affinity of α-GalCer for CD1d contributes to the robust immunological response α-GalCer produces, as analogs of α-GalCer that have a lower affinity for CD1d result in differential polarization of NKT cell”
• Going both ways: immune regulation via CD1d-dependent NKT cells. (2004, background): “One study suggested that NKT cell–derived IFN-γ exacerbated EAE, while NKT cell–derived IL-4 suppressed this disease (67); another showed that anti–IL-4 treatment had no effect on α-GalCer–mediated inhibition of EAE, while anti– IFN-γ treatment blocked this effect (64).”
• Immunology of multiple sclerosis. (2005, positive): “An analog of α-galactosylceramide (GalCer), a synthetic glycolipid that binds CD1d and stimulates mouse and human NKT cells, suppresses EAE by selective IL-4 induction (289).”
• Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria (2006, background): “Although we consider the substantial changes in antigenic potency due to subtle alkyl chain alterations unexpected, it is known that truncation or unsaturation of the lipid chains of α-GalCer can influence antigenic potency as well as the pattern of cytokine productio”
• Understanding pathogenesis and therapy of multiple sclerosis via animal models: 70 years of merits and culprits in experimental autoimmune encephalomyelitis research. (2006, background): “The group of Dr Yamamura stimulated the regulatory properties of NK T cells by using synthetic glycolipids (Miyamoto et al., 2001).”
• The biology of NKT cells. (2007, background): “This is particularly well established for cathepsin L because mutant thymocytes, but not DCs (perhaps owing to the redundancy of other cathepsins), failed to stimulate Vα14 NKT hybridomas in vitro and consequently failed to select NKT cells in vivo (112).”